Assessment of a Fixed-Dose Therapeutic Duo in Managing Elevated Blood Pressure and Lipid Imbalance

Abstract

This prospective observational study aimed to evaluate the results of using a combined daily dose of atorvastatin and amlodipine in patients diagnosed with both high blood pressure and abnormal blood lipid profiles, who were considered to have a moderate to high risk for cardiovascular events. The study enrolled 243 individuals with an average age of 63, all of whom were treated with one of four fixed-dose regimens (10/5 mg, 10/10 mg, 20/5 mg, or 20/10 mg). Over a three-month period, systolic and diastolic blood pressure readings at baseline (approximately 156/92 mm Hg) dropped to around 137/81 mm Hg by the end of the trial.

Alongside blood pressure improvement, favorable shifts were also seen in cholesterol levels: total cholesterol fell from 6.6 to 5.1 mmol/L, and low-density lipoprotein (LDL) dropped from 4.4 to 2.9 mmol/L. Only a small portion of participants (3.7%) discontinued the medication due to adverse effects. These findings suggest that a single-pill approach combining antihypertensive and lipid-lowering agents can be an efficient, well-tolerated strategy for patients facing multiple cardiovascular risks, potentially simplifying long-term disease management.